Bronchoscopic Lung Volume Reduction in a Sheep Model of Heterogeneous Emphysema
نویسنده
چکیده
We have previously described the use of bronchoscopic lung volume reduction (BLVR), a novel, tissue engineering-based, minimally invasive technique, in experimental homogeneous pulmonary emphysema in sheep. In this report, we describe the use of CTguided, site-directed BLVR in the treatment of experimental heterogeneous emphysema. Nine sheep were treated with localized papain instillations and nebulized papain to generate heterogeneous emphysema. Six animals subsequently underwent BLVR while the remaining 3 served as controls. The procedure was safe and well tolerated. BLVR reduced gas trapping (26.7%) as measured by RV-to-TLC ratio, improved diffusing capacity, and reduced a bullous lesion seen by
منابع مشابه
Bronchoscopic Lung Volume Reduction
The application of lung volume reduction surgery in clinical practice is limited by high postoperative morbidity and stringent selection criteria. This has been the impetus for the development of bronchoscopic approaches to lung volume reduction. A range of different techniques such as endobronchial blockers, airway bypass, endobronchial valves, thermal vapor ablation, biological sealants, and ...
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Lung volume reduction surgery (LVRS) and bronchoscopic lung volume reduction (bLVR) are palliative treatments aimed at reducing hyperinflation in advanced emphysema. Previous work has evaluated functional improvements and survival advantage for these techniques, although their effects on the micromechanical environment in the lung have yet to be determined. Here, we introduce a computational mo...
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Although many patients with severe emphysema have benefited from bronchoscopic lung volume reduction (BLVR) worldwide, experience of BLVR in Asian emphysema patients is scarce. Between July 2012 and March 2013, seven patients with advanced heterogeneous emphysema underwent BLVR in the Asan Medical Center. They had severe dyspnea and poor lung function (Modified Medical Research Council dyspnea ...
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Although lung volume reduction surgery improves survival in selected patients with emphysema, there has been ongoing interest in developing and evaluating bronchoscopic approaches to try to reduce lung volumes with less morbidity and mortality. The placement of endobronchial valves is one such technique, and although some patients have had a significant improvement, responses have been inconsis...
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BACKGROUND The development of bronchoscopic therapies for emphysema has renewed interest in collateral ventilation. The success or failure of bronchoscopically placed valves or biologic glues may be determined by collateral ventilation, which is exaggerated in emphysema. Furthermore, the validity of various animal models of emphysema for testing such techniques must be understood in the context...
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